经蝶入路垂体瘤切除术临床效果及其并发症

Clinical effect and its complications for transsphenoidal pituitary tumor resection

目的评价经蝶入路垂体瘤切除术临床效果并分析并发症发生情况及处理措施。方法回顾性分析我院2010年12月～2012年1月收治的46例垂体瘤患者的临床资料,均采用经蝶入路垂体瘤切除术治疗。其中,肿瘤全切除31例、次全切除10例、部分切除5例,观察患者的临床效果及并发症情况。结果所有患者手术均成功,无手术死亡病例,术后并发脑脊液鼻漏2例、高血糖7例、垂体功能低下8例、尿崩症19例,经对症处理均得到有效控制,出院时患者的身体状况及生活质量均明显改善,与术前比较存在显著性差异(P<0.05)。结论经蝶入路垂体瘤切除术临床效果满意,术后积极防治并发症可使其得到有效控制,患者的功能状态、体力状况及生活质量均得到明显改善。

Objective To evaluate the clinical effect and analyze the complication situation and management for transsphenoidal pituitary tumor resection. Methods The clinical data of 46 patients treated in our hospital from December 2010 to January g012 was retrospective analyzed. They were all taken with pituitary tumors, transsphenoidal pituitary tumor resection, in which the tumor totally remo- ving was in 31 cases, subtotal accounting for 10 cases, and partial resection was in five cases. The clini- cal effects and complications were observed. Results All surgeries were successful, and there was no one with operative deaths. There were two cases with postoperative cerebrospinal fluid rhinorrhea, seven ca- ses of high blood sugar, hypopituitarism in eight cases, 19 cases of diabetes insipidus. They had been ef- fectively controlled after symptomatic treatment, and discharge patients physical condition and quality of life were significantly improved. Compared with the preoperative presence, there were significant differences （P （0.05）. Conclusions The clinical effect for transsphenoidal pituitary tumor resection is satisfied. After surgery, positive prevention and treatment for the complications can make it controlled effectively, and the patient＇s functional status, physical condition and quality of life are sil^nifieantlv improved.