血清胱抑素C、β2微球蛋白和尿微量白蛋白的检测在早期糖尿病肾病诊断中的作用

Function of Cystatin C,β2MG,and Microalbuminuria Amounts at Diagnosing Early Diabetic Nephropathy

目的探讨血清胱抑素C（CysC）、β2微球蛋白（β2MG）、尿微量白蛋白（mA1b）在早期糖尿病。肾病（DN）诊断中的作用。方法用免疫比浊法对86例早期DN患者和50名健康人（对照组）血清中CysC、β2MG、尿mA1b分别进行检测分析。结果早期DN组的血清中CysC、β2MG、尿mA1b的含量均显著高于正常对照组（P〈0．01），三者异常检出率分别是79．1％、73.3％、62．8％，均显著高于正常对照组（P〈0．01），其中以CysC异常检出率最高。结论血清CysC与β2MG、尿mA1b一样，在诊断早期DN中具有重要作用。

Objective To discuss the function of Cystatin C, β 2MG,and microalbuminuria amounts at diagnosing early diabetic nephropathy（DN）.Method CysC, β 2MG and microalbuminuria contents in blood serum detected and analyzed of 86 early DN samples and 50 healthy samples for controls by means of Immunoturbidimetry.Results Contents for CysC, β 2MG and microalbuminuria in blood serum in early DN group（79.1%,73.3%,and 62.8% respectively） are significantly above that of normal controls（P 〈 0.01）.All these three numbers are higher than normal group（P 〈 0.01）.Among the three,detectable rate of abnormal CysC is of the highest.Conclusion CysC,similar as β2mG and microalbuminuria,plays an important role in diagnosing early DN.