2型糖尿病合并糖尿病足相关因素分析研究

Type 2 Diabetes Mellitus Diabetic Foot Study on Factors

目的:探讨2型糖尿病患者糖尿病足的危险因素。方法:对2009年1月至2011年12月我科住院的T2DM患者198例(糖尿病足组42例、非糖尿病足组156例)的临床资料和生化指标进行回顾性分析,然后进行多因素非条件Logistic回归分析。结果:DF组与NDF组在年龄、病程、吸烟史、2hPG、HbA1C、Scr、BUN、白蛋白UAER等因素的差异具有统计学意义(P<0.05);两组在性别、BMI、腰围、FPG、TG、TG、血清总蛋白、HDL-C、LDL-C、SBP、DBP、高血压病史等因素的差异无统计学意义(P>0.05);在多因素非条件Logistic回归分析时与DF相关的危险因素有病程、白蛋白、UAER(P<0.05)。结论:DF的发生与年龄、DM病程、吸烟史、血糖情况、白蛋白水平、Scr、BUN以及UAER等多因素有关,其中病程长、低白蛋白血症及UAER增高者DF发生的危险性明显增加。

Objective：To investigate the risk factors for type 2 diabetes diabetic foot.Methods：from January 2009 to December 2011 T2DM patients hospitalized in our department 198（group of 42 patients with diabetic foot,diabetic foot group of 156 non-cases） of clinical data and biochemical parameters were analyzed retrospectively,and then multivariate Logistic regression analysis.Results：DF group and the NDF group in age,disease duration,smoking history,2hPG,HbA1C,Scr,BUN,albumin UAER and other factors,a statistically significant difference（P0.05）;the two groups in gender,BMI,waist circumference,FPG,TG,TG,serum total protein,HDL-C,LDL-C,SBP,DBP,history of hypertension and other factors,the difference was not statistically significant（P0.05）;in a multifactor non-conditional Logistic regression analysis DF associated with disease risk factors,albumin,UAER（P0.05）.Conclusion： DF incidence with age,DM duration,smoking history,blood glucose,albumin level,Scr,BUN,and UAER and other factors,including longer duration,hypoalbuminemia and UAER increased the risk of occurrence of those DF increased significantly.