急诊应用胺碘酮治疗顽固性室性心动过速的疗效观察

Clinical Observation of Amiodarone for Emergency Treatment of Refractory Ventricular Tachycardia

目的:探讨急诊应用胺碘酮治疗顽固性室性心动过速的临床疗效。方法:对45例顽固性室性心动过速患者急诊应用胺碘酮治疗,观察转复疗效、胺碘酮用量及不良反应。结果:转复率为95.6%(43/45);胺碘酮静脉用量为1450～2200mg,平均(1750.5±120.0)mg;胺碘酮口服用量为120～600mg,平均(250.0±51.5)mg;2例患者出现血压下降,1例患者出现恶心、食欲差,2例患者出现心动过缓(<50次/min),不良反应发生率为11.1%(5/45);用药后LVEF均较用药前有显著改善(P<0.05),而HR、SBP、DBP、QTc、QTcd均无明显变化(P>0.05)。结论:胺碘酮能安全、快速而有效控制顽固性室性心动过速。

Objective：To investigate the clinical efficacy of the emergency application of amiodarone treatment of refractory ventricular tachycardia.Methods：45 cases of patients with refractory ventricular tachycardia emergency amiodarone treatment,observation cardioversion efficacy of amiodarone dosage and adverse reactions.Results：After transfection complex was 95.6%（43/45）;amiodarone intravenous dosage of 1450 ~ 2200mg（1750.5 ± 120.0） mg;120 ~ 600mg the Amiodarone oral dosage,the average（250.0±51.5） mg;drop in blood pressure in 2 patients,1 patient with nausea,poor appetite,two cases of patients with bradycardia（50 times/min）,the incidence of adverse reactions was 11.1%（5/45）;LVEF compared with medication after treatment before there were significant improvements（P0.05）,while the HR SBP and DBP,QTc and QTcd no obvious change（P0.05）.Conclusion： Amiodarone safe,fast and effective control of refractory ventricular tachycardia.