厄贝沙坦联合立普妥对永久性房颤患者血小板活化的影响

Effect of the Combined Application of Irbesartan and Liptor on Platelet Activation of Patients with Permanent AF

目的:探讨厄贝沙坦联合阿托伐他汀对永久性心房颤动患者血小板活化的影响。方法:将确诊为永久性房颤患者49例,随机分为治疗组25例和对照组24例,分别接受8周的厄贝沙坦联合阿托伐他汀和常规治疗。观察两组治疗前后的心室率的变化,测定GMP-40、TXB2。结果:两组治疗后心率控制均较治疗前显著改善,差异有统计学意义(P<0.05),但组间比较差异不显著。治疗后,实验组较对照组的GMP-40、TXB2水平显著下降,差异有统计学意义(P<0.05)。结论:厄贝沙坦联合阿托伐他汀在控制心室率上较常规治疗无优势,但可通过降低GMP-40、TXB2,抑制血小板活化,改善房颤患者的血栓前状态,这可能对预防血栓的形成起到重要作用。

Objective：To investigate the influence of irbesartan combining with atorvastatin on platelet activation in the patients with permanence atrial fibrillation.Methods：Forty nine patients with permanence atrial fibrillation were divided into treat group（25 cases） and control group（24 cases） randomly.Under the conventional therapy,the treat group also received irbesartan combining with atorvastatin for 8 weeks.To observe the changes of ventricular rate,blood plasma level of GMP-40andTXB2 before and after treatment.Results：The control of ventricular rate of both groups were better after treatment,the difference had statistical significance（P0.05）,but post-treatment difference between two groups was quiet.The blood plasma level of GMP-40andTXB2 of treat group were descendedremarkably than control group.Conclusion：Irbesartan combining with atorvastatin had no dominance in the control of ventricular rate,but it can cut down the blood plasma level of GMP-40andTXB2,restrainplatelet activation,and improve pro-thrombus state.It maybe have important effect in preventing thrombotic formation.