尿生化指标对原发性骨质疏松症治疗的评价

The Evaluation of Urinary Biochemical Indices of Primary Osteoporosis Treatment

目的:探讨检验尿生化指标对原发性骨质疏松症的治疗的评价价值。方法:回顾性分析我院收治的70例原发性骨质疏松的患者的临床资料,按照治疗方法的不同分为治疗组和对照组,对照组采用钙维生素D治疗,治疗组在对照组的基础上采用阿仑膦酸钠治疗,另选取健康体检组40例为正常组,测定病例组患者治疗前后及对照组的尿生化指标吡啶酚(PYD)、脱氧吡啶酚(DPD)、尿钙(Ca)及尿羟脯氨酸(HOP)。结果:病例组患者的PYD/Cr、DPD/Cr、Ca/Cr、HOP/Cr显著高于正常组,P<0.05。病例组治疗后的PYD/Cr、DPD/Cr较治疗前显著降低,P<0.05,且治疗组的改善效果要优于对照组,P<0.05。病例组治疗前后的Ca/Cr、HOP/Cr无显著性差异,P>0.05。治疗组和对照组无显著性差异,P<0.05。结论:PYD、DPD是原发性骨质疏松的较好的诊治指标,特异性较强,并不受饮食的影响。

Objective：To explore the inspection urine biochemical index to the treatment of primary osteoporosis evaluation value.Methods：retrospective analysis 70 patients with primary osteoporosis patients for clinical data,indicators PYD,DPD,Ca and urine HOP.Results：of the case group patients PYD/Cr,DPD/Cr,Ca/Cr,HOP/Cr significantly higher than normal group,P0.05.The case group therapy PYD/Cr,DPD/Cr is significantly lower before treatment,P0.05 Conclusion： PYD,DPD is a primary osteoporosis better diagnosis and treatment of the index,specificity is stronger,not under the influence of the diet.