急性苯丙胺类药物中毒88例临床分析

The Clinical Analysis of 88 Patients with Acute Amphetamine Poisoning

目的:观察急性苯丙胺类药物中毒的临床表现特点及治疗效果。方法:回顾性分析2010年1月至2012年6月急诊科诊治的急性苯丙胺类药物中毒患者88例的临床资料。结果:就诊人群以青年患者多见,年龄在25～28岁,78.4%为轻、中度中毒,且21%～41%合并有饮酒史。极重度患者罕见,但死亡率极高。与轻、中度中毒相比,重度中毒患者就诊时间短,但治疗周期延长,有一定死亡风险。发病时间以春夏季为主,而且夜间0点至清晨8点为就诊高峰期。结论:急性苯丙胺中毒以年轻人多见,病情以轻、中度中毒为主,治疗时间较短,预后较好;重度、极重度患者病情恶化快,治疗周期长,死亡率高。

Objective：To observe the clinical manifestation feature and effect of treatment of acute amphetamine poisoning. Methods： The clinical data of 88 patients with acute amphetamine poisoning diagnosed and treated in department of emergency were retrospectively analyzed from Jan 2010 to Jun 2012. Results： Young victims contributed to a large population of amphetamine poisoning with average age of 25 to 28 years. 78.4 % of the patients suffered from mild to moderate poisoning and it was rarely to worsen for profound condition, which indicted an unfavorable prognosis. For those in severe poisoning, it meant an extended period of treatment. It was found that a higher population of victims occupied in the period of 0 to 8 a.m. in a day and in the season of spring and summer. Conclusion：The young people easily suffer from acute amphetamine poisoning with mostly mild and moderate condition. Comparing with those patients in optimistic outcome, severe or profound patients would underwent a deteriorate state of poisoning and a higher risk of death.