摘要
目的研究28天慢性束缚应激对C57BL/6J雌鼠生理、繁殖性能及F1代仔鼠行为学的影响。方法采用28天慢性束缚应激和高架迷宫测试实验。结果 C57BL/6J雌鼠的体重、产仔数、仔鼠初生体重、雌鼠性周期差异极显著,但雌鼠的妊娠期、仔鼠离乳率、仔鼠离乳体重和C57BL/6J小鼠F1代仔鼠的焦虑行为学表现差异不显著;在应激实验结束时,小鼠体重及性周期有恢复现象。结论 28天慢性束缚应激对C57BL/6J雌鼠生理、繁殖性能及F1代仔鼠行为学的影响较大,但是C57BL/6J雌鼠妊娠期、仔鼠离乳率、仔鼠离乳体重和C57BL/6J小鼠F1代仔鼠的焦虑行为学表现未受其影响。
Objective To investigate effects of 28-day chronic restraint stress on the physiological index,reproduction performance and offspring anxiety-like behaviors of C57BL/6J female mice.Methods The 28-day chronic restraint stress and elevated plus maze test were applied.Results The result showed that the difference in gestation stage,offspring weaning weight,offspring weaning rate and offspring anxiety-like behaviors were not significant,while the difference in body weight,sexual cycle,litter size and offspring birth weight were significant.The body weight and sexual cycle gradually recovered at the latter stage.Conclusions The 28-day chronic restraint stress significantly affects physiological index and reproduction performance of C57BL/6J female mice,but chronic restraint stress has no effect on the duration gestational period,offspring weaning weight and offspring anxiety-like behaviors of C57BL/6J female mice.
出处
《疾病预防控制通报》
2012年第5期11-13,16,共4页
Bulletin of Disease Control & Prevention(China)
