急性冠脉综合征病人高敏C反应蛋白和同型半胱氨酸的相关性研究及其临床意义

目的探讨急性冠脉综合征(ACS)患者高敏C反应蛋白和同型半胱氨酸的相关性及临床意义。方法采用前瞻性研究方法,对2011年1月～2012年6月期间收治的急性冠脉综合征患者53例作为实验组,选取同期健康体检者53例,分别测定两组的血浆超敏C-反应蛋白(hs-CRP)和同型半胱氨酸(HCY)水平并进行分析。结果实验组和对照组外周血HCY、hs-CRP数值的比较,差异有统计学意义(P<0.05)。41例AMI患者各亚组间外周血HCY、hs-CRP数值的比较,各亚组间差异有统计学意义(P<0.05)。结论高敏C反应蛋白和同型半胱氨酸与急性冠脉综合征发病关系密切;联合检测外周血HCY、hs-CRP中的指标可以为冠心病的危险分层提供可靠的判断依据。

Objective To explore correlation and clinical significance of c-reactive protein（hs-CRP） and homocysteine（HCY） for acute coronary syndrome（ACS） patients.Methods By the prospective study method,53 patients of ACS in our hospital from January 2011 to June 2012 were as for the test group,53 patients of the same period the healthy check-up were as for control group,the plasma hs-CRP and HCY level of the two groups were determined and analyzed.Results The peripheral blood HCY and hs-CRP level of the two group be compared,difference was statistically significant（P0.05）.41 patients with AMI of HCY and hs-CRP level be compared,difference was statistically significant（P0.05）.Conclusion HsCRP and HCY have the close relationship of acute coronary syndrome;United detection of the index of hs-CRP and HCY can provide reliable basis for risk stratification of coronary heart disease.