氨茶碱两种不同用药方法治疗毛细支气管炎疗效观察

目的:观察氨茶碱单次静滴和分次氧驱动雾化吸入两种方法治疗毛细支气管炎的疗效。方法:113例毛细支气管炎患儿随机分治疗组和对照组,在抗感染、吸氧、止咳、维持酸碱平衡的基础上,治疗组60例给予氨茶碱3～5mg/(kg·日)分两次氧驱动雾化吸入,对照组53例给予氨茶碱等量单次静脉用药,并作显效、有效、无效、总有效率、不良反应发生率及气促、喘憋消失时间等作比较。结果:两组总有效率差异无统计学意义(P>0.05),对照组出现4例不良反应,治疗组无不良反应病例出现,差异有统计学意义(P<0.05),治疗组在气促、喘憋消失时间上与对照组差异有统计学意义(P<0.05)。结论:氨茶碱小剂量分次氧驱动雾化吸入与单次静脉用药治疗毛细支气管炎疗效相当,且未发现不良反应发生,气促、喘憋消失时间快,患儿顺应性好,易于配合。

Objective：To study the effect of single intravenous injection？ and oxygen atomizing inhalation of aminophylline for treating bronchiolitis.Methods：113 cases with bronchiolitis were randomly divided into treatment group and control group.all were given anti infection,oxygen inhalation,relieving cough and,maintenance of acid alkali balance.60 cases of treatment group were given oxygen atomizing inhalation of aminophylline 3 ～ 5mg / （kg·d）,53 cases of ontrol group while control group were given single intravenous injection.Result：There was no significant difference of total effect rate between two groups （ P 0.05）.there was difference of side effect rate between two groups.Four cases with side effect were found in control group.There was significant difference in disappearance time of short breath and wheezes between two groups.Conclusion：Oxygen atomizing inhalation of aminophylline for treating bronchiolitis has the same effect of single intravenous injection,and no side effect is found.The disappearance time of short breath and wheezes is shorter.it should be extended in clinic.