主动脉内球囊反搏治疗对晚期扩张型心肌病患者血浆脑钠尿肽的影响

Effect of intra-aortic balloon pump counterpulsation on serum brain natriuretic peptide in patients with terminal dilated cardiomyopathy

目的:观察主动脉球囊反搏(intra-aortic balloon pump,IABP)治疗在晚期扩张型心肌病(dilated cardiomyopa-thy,DCM)患者对血浆脑钠尿肽(brain natriuretic peptide,BNP)值变化的影响。方法:晚期DCM患者41例,在最优药物治疗基础上按是否应用IABP分为IABP植入组(植入组,21例),非植入组(对照组,20例)。免疫化学发光法测患者人院后第1、2、7天血浆BNP浓度。结果:入院第1天两组BNP值差异无统计学意义。入院后第2、7天,植入组BNP值明显低于对照组[(1778±289)ng/L vs.(2553±346)ng/L,P<0.05;(835±190)ng/L vs.(1376±301)ng/L,P<0.05]。结论:在最优药物治疗基础上,IABP能进一步降低晚期DCM患者BNP值。

AIM：To evaluate the efficacy and the safety of intra-aortic balloon pump（IABP） counterpulsation and its effect on the concentration of serum brain natriuretic peptide（BNP） in patients with terminal dilated cardiomyopathy（DCM）.METHODS： Forty-one patients with DCM complicated by pump failure were divided into IABP group（A： 21 cases） and control group（B： 20 cases） based upon the optimal medication.The plasma concentration of BNP was measured using chemiluminescence immunoassay at 1,2 and 7 days after admission.RESULTS： On the first day of admission,no statistical difference in the values of BNP concentration was observed between groups.On the second and the seventh day of admission,the values of BNP concentration in group A were lower than those in group B（1778±289） pg/ml vs.（2553±346） pg/ml,P0.05;（835±190） pg/ml vs.（1376±301） pg/ml,P0.05）.CONCLUSION： In patients with terminal DCM complicated with pump failure,IABP counterpulsation based upon the optimal medication is an effective and safe method to improve cardiac function and lower plasma BNP level.