在糖尿病和糖代谢异常/糖耐量异常患者中辛伐他汀治疗对血循环白细胞计数的影响

Association of circulating leukocyte count with diabetes mellitus and impaired fasting glucose/impaired glucose tolerance regression after simvastatin treatment

目的:观察应用辛伐他汀是否可以降低糖尿病和糖代谢异常(IFG)/糖耐量异常(IGT)患者血循环中白细胞计数(WBC)。方法:糖尿病患者(n=57)、IFG/IGT患者(n=42)和对照组(n=44),服用辛伐他汀(20 mg/d)6个月。3组患者均进行正常的体力活动,分别于治疗前和治疗6月后清晨空腹抽血测定白细胞计数、血浆总胆固醇(TC)和三酰甘油(TG),并统计其服药前后血压变化的情况。结果:糖尿病患者、IFG/IGT患者治疗后血循环中白细胞计数和中性粒细胞百分比显著减少(P<0.01,P<0.05),TG和TC在糖尿病、IFG/IGT组和正常对照组治疗后均明显降低(P<0.01或P<0.05)。结论:辛伐他汀可以明显降低糖尿病和IFG/IGT患者血循环中的WBC、中性粒细胞百分比。

AIM：To investigate the effects of simvastatin on the levels of peripheral blood leukocyte count,serum total cholesterol and triglycerides in patients with diabetes mellitus and impaired fasting glucose/impaired glucose tolerance（IFG/IGT）.METHODS： Diabetes mellitus patients [n=57,48 males,average age（74±9） years],IFG/IGT patients [n=42,35 males,average age（73±6） years] and controls [n=44,37 males,average age（74±7） years] were subjected to simvastatin treatment（20 mg/day） for 6 months.Patients in all three groups performed normal physical activity and plasma samples were collected after overnight fasting at baseline before and after the 6-month treatment for examination.RESULTS： Simvastatin treatment significantly reduced the peripheral blood leukocyte count and percentage of neutrophils in IFG/IGT and patients with diabetes mellitus（P0.01,P0.05）.Post-treatment levels of plasma triglycerides were significantly lower than those pre-treatment in patients with diabetes mellitus and IFG/IGT（P0.01）.Post-treatment levels of total plasma cholesterol were significantly lower compared with those pre-treatment in all three groups（P0.01,P0.05）.CONCLUSION： Simvastatin markedly lowered peripheral blood leukocyte count and plasma triglyceride levels and the percentage of neutrophils in patients with diabetes mellitus and IFG/IGT.Statin-induced inhibition of peripheral blood leukocyte count may play an important role in the pharmacological treatment of cardiovascular diseases.