VEGF对血管内皮细胞损伤的拮抗作用及作用机制

Protective effect and mechanism of vascular endothelial growth factor in vascular endothelial cell injury

冻结性冷损伤是以组织冻结再融化过程的病理改变为基础的损伤。已经证实,血管内皮细胞(VECs)除有屏障和膜转运功能外,还具有内分泌功能,主动参与了多种生命活动,对维持体内环境的平衡与稳定具有重要作用。冻伤过程中VECs的损伤,可促进微循环血栓形成造成微循环障碍;待到复温后,血液恢复流动又可导致不可逆的再灌注损伤。因此,减轻内皮细胞损伤,可以减少微循环血栓形成,从而减轻再灌注对机体造成的损伤。血管内皮细胞生长因子(VEGF)作为重要的血管生长因子,在冻伤时对VECs损伤具有拮抗作用,可通过促进血管再生、抗血栓形成、抑制血管平滑肌过度生长及抗炎的作用等实现的对血管的保护作用,为临床防治冻伤提供了新的思路。

Freezing cold injury is based on pathological changes of freezing and then melting processes in the injury.Many investigators have confirmed that vascular endothelial cells（VEC） with the barrier and membrane transport functions are larger endocrine organs in the body,which participate in a variety of life activities and play an important role in the balance and stability of the internal environment.VEC in the frostbite process can promote thrombus formation that may result in microcirculatory disturbance and cause irreversible reperfusion injury after blood rewarming and flowing.Mitigating the damage of endothelial cells can reduce the microcirculation thrombosis,thereby reducing the reperfusion injury.As an important vascular growth factor,vascular endothelial growth factor（VEGF） has some type of protective effect on VEC injury in frostbite.VEGF can provide a new approach for prevention and treatment of frostbite by exerting protective effects on vessels through promoting angiogenesis,inhibiting excessive growth of vascular smooth muscle,and anti-thrombosis or anti-inflammatory functions.