康复期肺癌患者癌因性疲乏与血清皮质醇激素相关性的初步研究

The Relationship Between Cancer Related Fatigue and Cortisol in Convalescent Patients with Lung Cancer

[目的]探讨康复期肺癌患者癌因性疲乏与血清皮质醇激素水平的关系。[方法]59例康复期肺癌患者分成疲乏组(39例疲乏患者)和非疲乏组(20例非疲乏患者),利用多维疲乏症状量表—简化版(MFSI-SF)和疲劳症状量表(FSI)对患者进行评估。电化学发光法检测血清皮质醇的水平,酶联免疫吸附法测定血清促肾上腺皮质激素(ACTH)的水平。[结果]疲乏组患者血清皮质醇水平低于非疲乏组(118.86±11.74nmol/L vs 166.43±62.82nmol/L,P<0.05),促肾上腺皮质激素水平高于非疲乏组(100.17±31.36ng/L vs 52.87±26.20ng/L,P<0.05)。疲乏组患者MFSI-SF评分与血清皮质醇激素水平呈负相关(r=-0.820,P<0.001),与血清促肾上腺皮质激素水平呈正相关(r=0.813,P<0.001);疲乏组患者FSI评分与血清皮质醇激素水平呈负相关(r=-0.778,P<0.001),与血清促肾上腺皮质激素水平呈正相关(r=0.629,P<0.001)。[结论]疲乏组患者癌因性疲乏评分增高,而血清皮质醇激素水平降低,促肾上腺皮质激素水平升高。血皮质醇激素水平低下在一定程度上影响康复期肺癌患者癌因性疲乏的严重程度。

[Purpose] To investigate the relationship between cancer related fatigue and cortisol in convalescent patients with lung cancer.[Methods] Fifty-nine cases with lung cancer were divided into fatigue group（39 cases with cancer-related fatigue） and no fatigue group（20 cases without fatigue）.The score were evaluated by Multidimensional Fatigue Symptom Inventory-Short（MFSI-SF） and The Fatigue Symptom Inventory（FSI）.Serum specimens were examined by electrical chemiluminescent immunoassay and enzyme-linked immunoadsordent assay.[Results]The level of cortisol in fatigue group was significant lower than that in no fatigue group（118.86±11.74nmol/L vs 166.43±62.82nmol/L,P0.05）,and the level of ACTH in fatigue group was significant higher than that in no fatigue group（100.17±31.36ng/L vs 52.87±26.20ng/L,P0.05）.There was negative correlation of cortisol with MFSI-SF（r=-0.820,P0.001）,and positive correlation with ACTH（r=0.813,P0.001）.There were negative correlations of cortisol with FSI（r=-0.778,P0.001）,and positive correlations with ACTH（r=0.629,P0.001）.[Conclusion] The MFSI-SF score increase,serum cortisol hormone reduce,and ACTH increase are found in patients with cancer-related fatigue.The level cortisol impacts on the severity of cancer-related fatigue in convalescent patients with lung cancer.