高压氧治疗改善轻、中度脑外伤患者睡眠质量的对照研究

Hyperbaric oxygen therapy in improving the scores of Pittsburgh Sleep Quality Index Questionnaire in patients with mild and moderate traumatic brain injury

目的观察高压氧(hyperbaric oxygen,HBO)治疗对轻、中度脑外伤患者睡眠质量的改善情况。方法连续选择住院治疗的轻、中度脑外伤67例,随机分为HBO组(34例)和对照组(33例),两组均接受闭合性脑外伤基础治疗,HBO组另行HBO治疗,压力为0.22 MPa,舱内氧浓度在23%以下,吸氧85 min/次,1次/d,10次为1疗程,共进行3个疗程。两组治疗前后分别接受"匹兹堡睡眠质量指数问卷(PSQI)"评估。结果两组治疗前PSQI各成分评分及PSQI总分分布接近(P>0.05),治疗后多数PSQI成分评分及PSQI总分均明显优于治疗前,HBO组治疗后多数PSQI成分评分及PSQI总分优于对照组(P<0.01或P<0.05)。结论 HBO治疗可明确改善轻、中度脑外伤患者睡眠质量。

Objective To study the status of hyperbaric oxygen（HBO） therapy in improving the scores of Pittsburgh Sleep Quality Index（PSQI） questionnaire in patients with mild and moderate traumatic brain injury.Methods Sixty-seven patients with mild and moderate traumatic brain injury,who were treated in this hospital recently,were successively recruited,and the subjects were randomly divided into HBO group（n=34） and control group（n=33）.All the patients in both groups were given the basic therapy for closed brain injury.Besides,those in the HBO group were treated with HBO,the pressure was 0.22MPa,the oxygen concentration in the cabin was controlled below 23%,oxygen uptake was 85min/time and lasted for100 minutes,once a day,and 10 times as a course for a total of 3 courses.All the patients were evaluated using Pittsburgh Sleep Quality Index（PSQI） questionnaire before and after therapy.Results Before therapy,the distributions of item scores of PSQI and the total score of PSQI were close between the two groups（P 0.05）.Most item scores of PSQI and the total score of PSQI after therapy were all significantly better than those before therapy in both groups,and most item scores of PSQI and the total score of PSQI after therapy in the HBO group were also better than those in the control group（P 0.01-0.05）.Conclusions HBO therapy obviously improves the sleep quality in patients with mild and moderate traumatic brain injury.