美多心安、鲁南欣康对心绞痛心率变异性的影响

Effects of Metoprolol and Isosorbidi Mononitras on Heart Rate Variability in Patients with Coronary Heart Disease

目的 观察美多心安、鲁南欣康对心绞痛心率变异性 (HRV)的不同影响。方法 对 38例及 36例心绞痛患者分别服用美多心安及鲁南欣康前后 2周作HRV检验及对比。结果 服用美多心安后 2 4h正常R R间期标准差 (SDNN) ,2 4h每 5min正常R R间期标准差 (SDANN) ,2 4hR R间期差值均方根 (rMSSD)及两个相邻R R间期差>5 0ms所占 2 4h内心率数的百分比 (PNN5 0 )较服药前有显著差异 (P <0 .0 5 ) ;鲁南欣康组服药 2周后除SDNN及rMSSD较服药前有显著差异 (P <0 0 5 )外 ,其他指标无显著变化。结论 两药均可改善心绞痛患者的HRV 。

objective To compare the effect of metoprolol and isosorbidi mononitras on heart rate variability(HRV)in patients with angian pectoris. Method 38 cases were given metoprolol 50mg bid for two weeks(metoprolol group),36 cases were given isosorbidi mononitras 60mg qd for two weeks (isosorbidi mononitras group).HRV were derermined before and after each two weeks medication.Results After metoprolol was administred for two weeks the rMSSD、SDNN、SDANN and PNN 50 four index in 24 hour time domain analysis,increased significantly( P <0.05);Also,it is found that after two weeks of isosorbidi mononitras administration SDNN and rMSSD was increased significantly( P <0.05).Conclusion These two drugs can help HRV of patients with coronary heart disease to develop toward a beneficial direction,and metoprolol is better.