期刊文献+

脐血LAK与CIK细胞杀伤活性研究 被引量:3

Experimetal Study on Lymphokine Activated Killer Cells' and Cytokine Induced Killer Cells' Activity of Cord Blood
下载PDF
导出
摘要 目的 寻求一种可用于过继免疫疗法的高效免疫活性细胞。方法 用多种细胞因子诱生CIK细胞 ,用MTT法测定LAK和CIK细胞杀伤活性。结果 在峰值期CIK细胞杀伤活性均显著高于LAK细胞 (P <0 .0 5 )。结论 CIK细胞与LAK细胞属不同的细胞毒性细胞 ,脐血CIK细胞的高杀伤活性提示其可能成为过继免疫疗法的生力军。 Objective To search for a kind of efficient and active immunocytes which can be used in transitional immunology therapy.Methods The cytotoxicity of CIK induced by multiple cytokines and LAK invitra was tested by MTT assays.Results During the peak period,the cytotoxicity of CIK is significantly higher than that of LAK.Conclusion CIK and LAK may be different cell populations.Fetal blood CIK may become a vivacions new method of transitional immunology therapy.
出处 《苏州医学院学报》 2000年第6期515-516,共2页 Acta Academiae Medicinae Suzhou
关键词 脐血 LAK CIK 杀伤活性 过继免疫疗法 fetal blood LAK CIK cytotoxicity
  • 相关文献

参考文献4

二级参考文献4

共引文献117

同被引文献24

  • 1林丽,陈忠平.细胞因子诱导的杀伤细胞体外抗胶质瘤的实验研究[J].中国神经肿瘤杂志,2003,1(2):69-72. 被引量:8
  • 2乔晓娟,李云霞.CIK细胞抗肿瘤的研究进展[J].医学综述,2004,10(12):711-713. 被引量:3
  • 3丁秀丽,蒋丽娜.自体CIK细胞治疗肿瘤的安全性评价[J].河北北方学院学报(医学版),2004,21(6):44-45. 被引量:9
  • 4陈明水,陈强,叶韵斌,李洁羽,陈淑萍,周智锋.CIK细胞的体外扩增及其抗肿瘤特性的研究[J].福建医药杂志,2004,26(6):162-164. 被引量:8
  • 5郭智,谭晓华,高锦,楼金星,刘晓东,何学鹏.CIK治疗耐药性非霍奇金淋巴瘤疗效观察[J].实用癌症杂志,2006,21(1):15-16. 被引量:29
  • 6Christine H,Charles DB,Bangs, et al.Negrin expansion of philadelphia chromosome-negative CD3^+CD56^+ cytotoxic cells from chronic myeloid leukemia patients:in vitro and in vivo efficacy in severe combined immunodeficiency [J].Blood, 1998,92(9):3318-3327.
  • 7Finke S,Trojaneck B,Lefterova P, et al.Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3^+CD56^+ immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene [J].Gene Ther,1998,5(1):31.
  • 8ZOLL B,LEFTEROVA P,EBERT O,et al.Modulation of call surface markers on NK-like T lymphocytes by using IL-2,IL-7or IL-12 in vitro stimulation[J].Cytokine,2000,12(3):1385-1390.
  • 9ZOLL B,LEFTEROVA P,CSIPAI M,et al.Generation of cytokine-induced killer cells using exogenous interleukin-2,-7or12[J].Cancer Immunol Immunother ,1998,47(3):221-226.
  • 10MARTEN A,ZISKE C,SCHOTTKER B,et al.Interactions between dendritic cells and cytokine-induced killer cells lead to an activation of both populations[J].J Immunother,2001,24(5):502-510.

引证文献3

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部