瘤内微血管密度与胃癌临床病理特征相关性研究

The Study of the Relationship between Intratumor Microvessel Density and the Clinicopathological Features of Gastric Carcinoma

目的 探讨肿瘤内血管生成在胃癌生长、侵袭、转移中的作用。方法 采用免疫组织化学SP法 ,用抗血管内皮CD34单克隆抗体对 40例胃癌及 10份正常胃组织标本进行标记分析。结果 肿瘤微血管密度 (MVD)较正常胃组织显著增高 (P <0 .0 1) ;淋巴结转移组MVD显著高于无淋巴结转移组 (P <0 .0 1) ;肿瘤肝脏转移组MVD较无肝转移组增高 (P <0 .0 5 )。结论 瘤内血管密度与胃癌的侵袭、转移密切相关 ,血管生成可能促进胃癌的发展并影响其预后。

Objective To evaluate the role of angiogenesis in growth、invasion and metastasis of gastric carcinoma.Methods The microvessel density(MVD)was determined by immunohistochemical SP method using a monoclonal antibody to CD 34 in samples of 40 gastric carcinoma and 10 normal gastric tissue.Results MVD was significantly higher in carcinoma than that in normal gastric samples( P <0.01)and higher in the groups with lymphnode involvement or liver metastases than that without lymphnode involvement or liver metastases( P <0.01 and P <0.05 Respectively).Conclusions Intratumor MVD is strongly related to the invasion and metastasis of gastric carcinoma. Angiogenesis might promote the progression of gastric carcinoma and affect the prognosis of the patients.