氨基磺酸催化合成尿囊素

Synthesis of Allantoin Catalyzed by Sulfamic Acid

以尿素、乙醛酸为原料,氨基磺酸为催化剂合成尿囊素。采用正交实验法研究反应温度、原料配比(n尿素∶n乙醛酸)、催化剂用量、反应时间等因素对尿囊素收率的影响。分析表明,催化剂用量和反应温度影响显著,而配比和反应时间影响不显著。根据实验具体情况、原料经济性、安全环保等因素,确定了最佳合成条件:反应温度为70℃,原料配比(n尿素∶n乙醛酸)为3.5∶1,催化剂氨基磺酸的用量为4g,反应时间为6h。尿囊素收率可达51.73%。

Allantoin was synthesized with glyoxylic acid and urea as raw materials,sulfamic acid as catalyst by orthogonal experiment.The effects of reaction temperature,ratio of raw materials,reaction time and dosage were studied.The optimal reaction conditions were as followed： n（urea） ： n（glyoxylate） = 3.5,catalyst amount 4.0g,reaction temperature 70℃,reaction time 6h.Under the optimal conditions,the yield of allantoin was 51.73%.