KAI1蛋白在甲状腺乳头状癌及滤泡癌组织中的表达及临床意义

Significance of KAI1 protein expression in tissues of papillary thyroid cancer and follicular thyroid cancer

目的探讨KAI1蛋白在甲状腺乳头状癌（PTC）和滤泡癌组织中表达及其在PTC浸润和转移中的作用。方法回顾性分析2006年1月至2009年8月收治的58例PTC患者（PTC组）、17例甲状腺滤泡癌患者（滤泡癌组）和30例甲状腺良性肿瘤患者（对照组）的临床资料，采用免疫组织化学方法测定PTC组织、甲状腺滤泡癌组织和甲状腺良性肿瘤组织中KAI1蛋白的表达。结果KAI1蛋白在PTC组阳性表达率为48．3％（28／58），滤泡癌组为47．1％（8／17），对照组为86．7％（26／30），PTC组、滤泡癌组与对照组比较差异有统计学意义（P〈0．01），而PTC组与滤泡癌组比较差异无统计学意义（P〉0．05）。PTC组KAI1蛋白表达在患者性别、年龄及原发病灶直径之间比较差异无统计学意义（P〉0．05）。KAI1蛋白在肿瘤的TNM分期I期的阳性表达率为88．9％（8／9）、11期为60．9％（14／23）、Ⅲ～Ⅳ期为23．1％（6／26），不同TNM分期的KAll蛋白阳性表达率比较差异有统计学意义（P〈0．01）；KAI1蛋白在有淋巴结转移的PTC组织中和无淋巴结转移的PTC组织中的阳性表达率分别为32．3％（10／31）和66．7％（18／27），两者比较差异有统计学意义（P〈0．05）。结论KAI1蛋白表达可反映PTC的转移能力以及临床演进程度，KAI1蛋白可能对PTC的浸润和转移有抑制作用。

Objective To investigate the expression of KAI1 protein in tissues of papillary thyroid cancer （PTC） and follicular thyroid cancer, and the effect of KAI1 protein in invasion and metastasis of PTC. Methods The clinical data of 58 patients with PTC （PTC group）, 17 patients with follicular thyroid cancer （follicular cancer group） and 30 patients with benign thyroid tumor （control group） were retrospectively analyzed from January 2006 to August 2009. The expression of KAI1 protein in PTC tissues, follicular thyroid cancer tissues and benign thyroid tumor tissues were detected by immunohistochemistry method. Results The positive expression rate of KAI1 protein in PTC group was 48.3%（28/58 ）, in follicular cancer group was 47.1% （8/17 ）, in control group was 86.7 % （26/30）. There was significant difference between PTC group, follicular cancer group and control group （P〈 0.01 ）. There was no significant difference between PTC group and follicular cancer group （P〉 0.05）. There was no significant difference in the positive expression rate of KAI1 protein of PTC tissues among the different sex, age and size of the primary lesion （P 〉 0.05 ）. The positive expression rate of KAI1 protein in the TNM I was 88.9% （8/9）, the TNM 11 was 60.9% （14/23） and the TNM III- IV was 23.1% （6/26）, there was significant difference in the positive expression rate of KAI1 protein among the different TNM stage （P 〈 0.01 ）. The positive expression rate of KAI1 protein in the lymph node metastasis patients was 32.3% （10/31）,the non-lymph node metastasis patients was 66.7% （18/27）, there was significant difference （P 〈 0.05 ）. Conclusion The expression of KAI1 protein may reflect the PTC metastasis and the clinical evolution of tumors, the KAI 1 protein may inhibit the invasion and metastasis of PTC.