不同血糖水平急性脑梗死患者血栓调节蛋白比较

Comparison of thrombomodulin in acute cerebral infarction patients with different blood glucose levels

目的比较不同血糖水平急性脑梗死患者血栓调节蛋白水平。方法选择急性脑梗死患者489例，其中无糖尿病237例（无糖尿病组），糖尿病血糖控制良好117例（血糖良好组），糖尿病血糖控制不佳135例（血糖不佳组），比较各组间血栓调节蛋白水平。结果无糖尿病组血栓调节蛋白水平为（2．66±1．20）μg／L，血糖良好组为（2．80±1．43）μg／L，血糖不佳组为（3．22±1．60）μg/L，三组间血栓调节蛋白水平呈逐渐升高趋势，差异有统计学意义（P=0．030）。组间两两比较，无糖尿病组血栓调节蛋白水平与血糖不佳组比较差异有统计学意义（P=0．008）。结论急性脑梗死患者血糖控制不佳时血栓调节蛋白水平升高。

Objective To compare the levels of thrombomodulin in acute cerebral infarction patients with different blood glucose levels. Methods Four hundred and eighty-nine patients with acute cerebral infarction were selected including 237 patients of non-diabetes （non-diabetes group ）, 117 patients of diabetes and HbAlc ≤7.0% （diabetes controlled well group） and 135 patients of diabetes and HbAIe 〉 7.0% （diabetes controlled badly group）. The level of thrombomodulin was assayed by enzyme-linked immunosorbent assay and compared among three groups. Results The level of thrombomodulin was （2.66 ± 1.20） μg/L in non-diabetes group, （2.80 ± 1.43） μg/L in diabetes controlled well group, （3.22 ± 1.60） μg/L in diabetes controlled badly group. There was the increasing of thrombomodulin among non-diabetes group, diabetes controlled well group and diabetes controlled badly group （P = 0.030）. There was difference between non-diabetes group and diabetes controlled badly group （P = 0.008 ）. Conclusion There is the increasing of thrombomodulin in patients with acute cerebral infarction when their blood glucose rising.