索他洛尔与美西律治疗室性早搏60例比较

Sotalol vs mexiletine in treating ventricular premature beats

目的 :比较索他洛尔 ( Sot)与美西律 ( Mex)对频发性室性早搏的疗效。方法 :6 0例频发性室性早搏患者 ,采用双盲随机试验 ,分为 Sot组与 Mex组。 Sot组初始治疗剂量为 80 m g bid po,最大剂量为 16 0 m g bid po。 Mex组初始剂量为 15 0 mgtid po,最大剂量为 2 0 0 mg qid po。结果 :Sot组总有效率为 83.33% ,Mex组总有效率为 73.33% ,两组间无显著差异。结论 :Sot与

AIM:To compare the effects of sotalol and mexiletine in treating ventricular premature beats. METHODS: Sixty patients with ventricular premature beats were randomly divided into 2 groups. Sotalol was administered in doses of 80 mg bid po, and the maximun doses were 160 mg bid po. In control group 30 patients received mexiletine 150 mg tid po, its maximum doses were 200 mg qid po. RESULTS: The total effective rate was 8333% in sotalol, and was 7333% in mexiletine. It was no significant difference between 2 groups. CONCLUSION: The 2 drugs have same effects on ventricular premature beats.