D-聚甘酯对原代培养胎大鼠皮层神经元细胞外液NO的影响

EFFECTS OF D-MANNORONICATE ON EXTRACELLULAR NO LEVEL IN PRIMARY CULTURED RAT CORTICAL NEURONS

体外培养胎大鼠皮层神经元 ,利用低糖低氧环境造成脑缺血模型 ,观察了 D-聚甘酯对低糖低氧所致NO释放的影响。结果表明 D-聚甘酯 5,2 5,50 mg· L-1不能抑制低糖低氧所导致的 NO释放的增多。提示 D-聚甘酯可能以非

The effects of DMannuronicate on extracellular nitric oxide(NO)levels were investigated in primary cultured rat cortical neuronal cells.NO was measured by using spectrometry. The results showed that DMannuronicate 5、25、50mg·L 1 could not inhibit the elevation of NO in prmary cultured neurons that were exposed for 8h to hypoxic and hypoglycemic situation,suggesting that DMannuronicate dont exert neuroprotective effects by influencing the production of NO after ischemic damage.