异维A酸联合放疗治疗9例蕈样肉芽肿

Treatment of mycosis fungoides with isotretinoin and radiation therapy

应用异维A酸 0 75mg/(kg·d) ,结合浅层放射治疗 9例蕈样肉芽肿患者 ,其中 6例为斑块期 ,3例为肿瘤期。每例患者照射总剂量为 16GY。治疗 2个月后 8例患者 90 %的皮损痊愈 ,结节损害由平均 11个减为 1个。此联合疗法与单独口服异维A酸或放射治疗相比 ,可缩短疗程、减少剂量 ,且副作用小。

Nine cases of mycosis fungoides were treated with isotretinoin [0 75mg/(kg d)] and superficial X ray irradiation to nodule lesions There were 6 cases in plaque stage and the others in tumor stage The total dose of irradiation of each case was 16 GY The 90%skin lesions of 8 cases were cured after two months The average number of nodules was reduced from 11 to 1 Good therapeutic effect was obtained with less side effects In comparison with the single treatment (isotretinoin or X ray irradiation alone), the combined regimen can shorten duration of treatment and reduce the dose of irradiation or isotretinoin