冠心病患者血清铁测定及临床意义

Serum iron levels and it's clinical significance in subjects with coronary heart disease

目的 :探讨冠心病 (CHD)患者血清铁水平及 CHD患者不同性别、族别、急性心肌梗塞 (AMI)不同时间的血清铁水平及其动态变化。 方法 :测定 87例冠心病患者 (13例 AMI)、80例健康对照组不同时间的血清铁蛋白(SF)、血清铁 (SI)水平并进行比较。结果 :冠心病患者血清铁水平明显高于对照组 (P <0 .0 1) ,男性 CHD患者 SF升高较女性患者更为显著 (男性 P <0 .0 0 1,女性 P <0 .0 5 )。结论 :男性汉、维吾尔族 CHD发病与血清铁增加有关 ;CHD发病的性别差异与 SF性别差异有关 ;AMI患者 SI水平呈现下降、恢复的动态改变 ;SF水平高低不能用来估价

Objective: To Study serum iron levels in subjects with coronary heart disease (CHD) and in different sex,nationality with CHD, different time with AMI. Methods: We measured serum ferritin (SF), serum iron (SI) in 87 patients with CHD, in which 13 cases with AMI and 80 healthy subjects matching for age served as control. Results: serum iron levels were obviously higher in CHD group than in control, and the increased levels were higher in male patients than in female patients (P<0.001 and 0.05). serum iron levels in Han, Uygur patients with CHD were all obviously higher than normal control (P<0.01). Ferritin levels in patients with AMI had significant difference (P<0.01), but serum levels had no difference in different time (P>0.05). Conclustion: There is a relationship between CHD and increasing of serum iron. The sex difference of patients with CHD had correlation with the sex difference of SF; SI levels showed decreasing recovering changes in patients with AMI. SF levels cannot estimate serious degree and area of myocardial infarction.