雌、孕激素受体在原发性胆囊癌组织中的表达及其临床意义

Clinical significance of the expression of ER and PR in primary gallbladder carcinoma and chronic cholecystitis

目的 :探讨雌激素受体 (ER)、孕激素受体 (PR)在原发性胆囊癌组织中的表达及其临床意义。方法 :应用免疫组化 (L SAB)法 ,对 46例胆囊癌及 30例慢性胆囊炎组织中 ER、PR的表达进行检测。结果 :46例胆囊癌组织中 ER、PR的阳性检出率分别为 39.1% (18/ 46 )和 36 .9% (17/ 46 ) ;30例慢性胆囊炎组织中 ER、PR的阳性检出率分别为 13.3% (4 / 30 )和 10 .0 % (3/ 30 ) ,癌与炎性病变之间有明显差异 (P均 <0 .0 5 )。高分化腺癌 ER和 PR的阳性检出率分别为 5 8.3% (14/ 2 4)和 5 4.2 % (13/ 2 4) ,低分化腺癌 ER、PR的阳性检出率均为 18.2 % (4 / 2 2 ) ,二者有显著性差异 (P均 <0 .0 5 )。结论 :检测 ER、PR对了解胆囊癌激素依赖性及指导临床内分泌治疗有意义 ;ER。

Objective: To study the expressions of ER (estrogen receptor) and PR (progesterone receptor ) and their possible effects on primary gallbladder carcinogenesis. Methods: Expressions of ER and PR in 46 specimens of patients with primary gallbladder carcinoma and 30 specimens of chronic cholecystitis were detected by LSAB immunohistochemistry. Results: The detected rates of ER and PR expression were 39.1%(18/46) and 36.9%(17/46) in neoplastic lesions, it revealed higher frequency than those in inflammatory lesions respectively (P<0.05). The frequency of ER and PR expression was 58.3%(14/24) and 54.2%(13/24) in well differentiated tumor tissues, more lower than that in poor differentiated tumor tissues (P< 0.05). Conclusions: 1. ER and PR may involve some bioactivity of regulation of gallbladder carcinogenesis. 2. Primary gallbladder carcinoma could be a hormone dependent tumor. Therefore, detection of ER or/and PR could offer evidence for surgical treatment and endocrime therapy.