血液灌流联合血液透析治疗中毒致急性肾功能衰竭的疗效观察

Observation of hemoperfusion combined with hemodialysis treating acute renal failure caused by poisoning

目的探讨血液灌流（Hemoperfusion，HP）联合血液透析（Hemodialysis，HD）治疗中毒致急性肾功能衰竭（AcuteRenalFailure，ARF）的疗效。方法回顾性分析58例中毒致ARF患者，其中30例采用血液灌流联合血液透析（HP＋HD）治疗，28例采用单纯血液透析（HD）治疗，两组均同时给予常规治疗。比较两组的平均住院时间、清醒时间、肾功能恢复时间、透析时间、治愈率以及出院时血肌酐水平等生化指标的差异。结果HP＋HD组患者住院天数、清醒时间、肾功能恢复时间、脱离透析时间较HD组明显缩短，血肌酐水平明显降低，治愈率高，差异显著，有统计学意义（P〈0．05）。结论血液灌流联合血液透析治疗能促进中毒致ARF患者肾功能恢复，提高治愈率，具有较好的临床应用价值。

Objective Explore the effect of Hemoperfusion （HP） combined with hemodialysis （HD） treating acute renal failure caused by poisoning. Methods Retrospective analysis of 58 cases of acute renal failure caused by poisioning between October 2008 and September 2011 was conducted, of which 30 cases were treated with hemoperfusion combined with hemodialysis （HP ＋ HD）, and 28 .of them were treated with hemodialysis. On top of the treatments provided respectively, both groups were also given the conventional treatment. The comparison between the two groups was made on hospital stay, awake time, renal function recovery time, duration of dialysis, recovery rate, serum keratinize level, and other biochemical markers at discharge. Results It reflected that hospital stay, awake time, renal function recovery time and duration of dialysis of patients were significantly shorter in HP＋HD group than HD group; Serum keratinize levels of patients were significantly lower in HP＋HD group than HD group; Recovery rate of patients was significantly higher in the HP＋HD group than HD group （P〈0.05）. Conclusion Hemoperfusion combined with hemodialysis treating acute renal failure caused by poisioning may promote recovery of renal function of patients and improve cure rate, carrying out a better clinical value.