3764例女性泌尿生殖道支原体培养及药敏结果的分析

3764 Cases of Female Urogenital Mycoplasma Culture and Susceptibility Results

目的了解本地区女性生殖道疾病中支原体感染及常用药物体外药敏状况,为指导临床合理用药提供依据。方法应用珠海丽拓试剂公司提供的支原体鉴定药敏试剂盒对3764例门诊患者的泌尿生殖道分泌物进行支原体的培养、鉴定及药敏试验,并对12种抗菌药物对支原体的敏感性进行回顾性统计分析。结果 3764例门诊标本中,支原体检出阳性2041例,阳性率54.32%,其中解脲脲原体Uu阳性1655例(占43.97%);人型支原体Mh阳性18例,(占0.48%);Uu+Mh混合感染阳性368例(占9.87%)。药敏试验显示药敏试验显示Uu、Uu+Mh、Mh的耐药性存在一定差异,单纯Uu感染者对抗生素的敏感性明显高于混合感染者。交沙霉素、强力霉素、美满霉素对支原体敏感性最高。结论支原体感染以Uu感染为主,不同地区、不同支原体类型和是否混合感染对抗菌药物的敏感性存在差异,临床应根据感染类型及抗菌药物敏感性的不同选择有效的抗生素进行治疗。

Objective To study the infection of female genitourinary tract with Mycoplasma and the susceptibility of commonly used drugs in vitro conditions in local area,to provide reference for antibiotic selection in the clinical treatment.Methods Cultivation and drug sensitivity test were adopted to 3674 our patients’ samples by Application of zhu hai LiTuo.And the results of 12 kinds of drug sensitivity tests to mycoplasma were analyzed.Results 2041 cases were detected positive for mycoplasma among 3764 patients’ samples,positive detection rate of 54.32%.Among these patients positive Uu and positive Mh were founded in 1655 cases（43.97%）,18 cases（0.48%）respectively.And the mixed infection by Uu and Mh were 368 cases（9.87%） respectively.Drug sensitivity tests showed that the difference between the drug resistance of Uu,Uu＋Mh,Mh was obvious.the drug sensitivity in simplex infection with Uu was higher than simplex infection with Mh complex infection.josamycin,deoxycycin,minocycine were most sensitive to mycoplasma.Conclusion Mycopplasma infention in genitourinary tract mainly caused by Uu,the antibiotic resistance of mycoplasma is different in vary areas and the infection kinds of mycoplasma single or mixed infection decided the different of drug sensitivity.So clinical doctors should select appropriate antibiotic for clinical treatment according to differences in infection type and drugs fragment.