期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

西妥昔单抗联合GP方案治疗晚期非小细胞肺癌的临床观察 被引量：4

下载PDF
导出
摘要 目的探讨西妥昔联合GP(吉西他滨和顺铂)方案治疗非小细胞肺癌(NSCLC)的临床疗效。方法将我院2010年-2012年收治的90例晚期非小细胞肺癌患者分为观察组及对照组,各45例,两组患者均采用GP方案化疗,观察组患者在此基础上联合西妥昔单抗,评价近期疗效及化疗前后血清癌胚抗原(CEA)、糖类抗原(CA-125)、表皮生长因子受体(EGFR)变化情况。结果观察组患者临床缓解率与对照组比较无统计学意义(P>0.05);观察组稳定率高于对照组,两组患者比较差异有统计学意义(P<0.05);观察组患者CEA、CA-125、EGFR水平下降明显,与对照组患者比较差异有统计学意义(P<0.05)。结论西妥昔单抗联合一线药物治疗晚期NSCLC,近期疗效疗效满意,对降低患者肿瘤相关指标有明显作用。
作者 高吉俊 崔敬敬 周鹏云
机构地区 滨州市滨城区市立医院肿瘤科
出处 《中国医药指南》 2012年第31期566-567,共2页 Guide of China Medicine
关键词 西妥昔单抗 吉西他滨 顺铂 非小细胞肺癌 临床观察
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献5

二级参考文献68

  • 1李艳,王新允,刘婷,朱丛中,孙翠云,王爱香,郑海燕,赵凤云.组织芯片技术研究肺癌及癌前病变bFGF的表达和意义[J].肿瘤防治杂志,2005,12(9):668-671. 被引量：5
  • 2马洪,冯红超,宋宇峰,陈永娟.口腔癌中VEGF和VEGF-C表达的相关性研究[J].贵阳医学院学报,2006,31(3):226-228. 被引量：1
  • 3孙海,耿建,金洁,陈龙邦.人肺腺癌细胞系SPC-A1多西他赛耐药细胞系的建立及其特性[J].中国癌症杂志,2007,17(4):283-287. 被引量：6
  • 4Muley T, Fetz TH, Dienemann H, et al. Tumor volume and tumor marker index based on CYERA 21--1 and CEA are strong prognostic factors in operated early stage NSCLC[J]. Lung Cancer, 2008, 60(3): 408---415.
  • 5Shimanuki Y, Takahashi K, Cui R, et al. Role of serum vascular endothelial growth factor in the prediction of angiogenesis and prognosis for non-small cell lung cancer[J]. Lung, 2005, 183(1): 29--42.
  • 6Jiang X, ZhouJH, Deng ZH, et al. Expression and significance of Notchl,Jaggedl and VEGF in human non--small cell lung cancer[J]. Zhong Nan Da Xue Xue Ban Yi Xue Ban[J]. 2007, 32(6): 1031-1036.
  • 7Tas F, Duranyildiz D, Oguz H, et al. Serum vascular endothelial growth factor (VEGF) and bcl-2 levels in advanced stage non--small cell lung cancer[J]. Cancer Invest, 2006, 24(6): 576---580.
  • 8Kim HS, Park NH, Chung HH, et al. Serum CA-125 level after 6 cycles of primary adjuvant chemotherapy is a useful prognostic factor for complete responders' survival in patients with advanced epithelial ovarian cancer[J]. Onkologie, 2008, 31 (6) : 315-320.
  • 9Chiu CH, Shih YN, Tsai CM, et al. Serum tumor markers as predictors for survival in advanced non-small cell lung cancer patients treated with gefifinib[J]. Lung Cancer, 2007, 57(2): 213-221.
  • 10KulpaJ, Wojcik E, Reinfuss M, et al. Carcinoembryonic antigen, squamous cell carcinoma antigen, CYFRA 21-1, and neuron-specific enolase in squamous cell lung cancer pafients[J]. Clin Chem, 2002, 48(11): 1931-1937.

共引文献28

同被引文献37

  • 1Makitaro R,Paakko P,Huhti E,et al.Prospective population-based study on the survival of patients with lung cancer[J].Eur Respir J,2002,19(6):1 087.
  • 2Potosky AL,Saxman S,Wallace RB,et al.Population variations in the initial treatment of non-small-cell lung cancer[J].J Clin Oncol,2004,22(16):3 261.
  • 3Mok TS,Wu YL,Thongprasert S,et al.Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma[J].N Engl J Med,2009,361(10):947.
  • 4Rosell R,Carcereny E,Gervais R,et al.Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer(EURTAC):a multicentre,open-label,randomised phase 3 trial[J].Lancet Oncol,2012,13(3):239.
  • 5Sandler A,Gray R,Perry MC,et al.Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer[J].N Engl J Med,2006,355(24):2 542.
  • 6Soria JC,Mauguen A,Reck M,et al.Systematic review and meta-analysis of randomised,phaseⅠ/Ⅰtrials adding bevacizumab to platinum-based chemotherapy as first-line treatment in patients with advanced non-smallcell lung cancer[J].Ann Oncol,2013,24(1):20.
  • 7Azzoli CG,Baker SJ,Temin S,et al.American society of clinical oncology clinical practice guideline update on chemotherapy for stageⅠnon-small-cell lung cancer[J].J Clin Oncol,2009,27(36):6 251.
  • 8Bunn PA.Chemotherapy for advanced non-small-cell lung cancer:who,what,when,why?[J].J Clin Oncol,2002,20(18 Suppl):23.
  • 9D’Addario G,Felip E.Non-small-cell lung cancer:ESMO clinical recommendations for diagnosis,treatment and follow-up[J].Ann Oncol,2008,19(Suppl 2):ii39.
  • 10Grossi F,Aita M,Defferrari C,et al.Impact of third-generation drugs on the activity of first-line chemotherapy in advanced non-small cell lung cancer:a meta-analytical approach[J].Oncologist,2009,14(5):497.

引证文献4

二级引证文献11

中国医药指南
2012年 第31期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部