miRNA单核苷酸多态性与大肠癌的研究进展

Advances in understanding relationship between miRNA single nucleotide polymorphisms and colorectal cancer

大肠癌(colorectal cancer,CRC)的发生、发展是一个多因素多步骤的演进过程,基因多态性是决定肿瘤发生、发展及预后的一个重要因素.近年研究发现某些microRNA(miRNA)的单核苷酸多态性(single-nucleotide polymorph-ism,SNP)与CRC遗传易感性及预后相关,阐明相关改变机制可为CRC的早期筛查、预防及预后监测提供新线索.本文就相关研究进展作一综述.

The occurrence and development of colorectal cancer （CRC） are a multifactorial, multistep evolutionary process. Gene polymorphisms are often involved in tumor development and prog nosis. Recent studies have found that certain microRNA （miRNA） single nucleotide polymorphisms were associated with genetic susceptibility to and prognosis of CRC. Understanding the relationship between miRNA single nucleotide polymorphisms and CRC can provide new clues to the detection, prevention, and prognostic evaluation of CRC.