锡类散治疗溃疡性结肠炎疗效的系统评价

Eff icacy of Xileisan in patients with ulcerative colitis:A systematic review

目的:系统评价国内以锡类散为主治疗溃疡性结肠炎的临床随机对照试验的疗效.方法:根据纳入标准搜集相关文献,筛选合格研究,应用Jadad评分法进行质量评价,运用异质性检验、Meta分析、漏斗图分析等方法统计相关数据.结果:纳入符合标准文献21篇,Jadad评分普遍不高.纳入研究的总有效率和治愈率分析均显示锡类散治疗组明显优于对照组(单纯西药组),总有效率[比值比(Oddsratio,OR)=5.29,95%可信度区间(confidence interval,CI):3.67-7.63,P<0.00001],治愈率(OR=3.65,95%CI:2.61-5.12,P<0.00001),不良反应发生率治疗组低于对照组(OR=0.53,95%CI:0.32-0.86,P=0.01).漏斗图分析显示存在发表性偏倚.结论:尚需更多的高质量的前瞻性多中心随机对照研究为临床提供更加可靠的证据,从而对锡类散的疗效予以证实.

AIM：To systematically evaluate the clinical effi cacy of Xileisan in the treatment of ulcerative colitis.METHODS：Relevant literature was collected based on the inclusion criteria,and the Jadad scale was used to rate the quality of the trials.Statistical analyses were performed using the test for hetero-geneity,meta-analysis,and funnel plot analysis.RESULTS：A total of 21 publications were included,and their Jaded scores were generally not high.The total response rate（OR = 5.29,95%CI：3.67-7.63,P 0.00001） and cure rate（OR = 3.65,95%CI：2.61-5.12,P 0.00001） for the Xileisan treatment group were signifi cantly bet-ter than those for the control group（only west-ern medicine group）.Adverse reaction rate for the treatment group was signif icantly lower than that for the control group（OR = 0.53,95%CI：0.32-0.86,P = 0.01）.Funnel plot analysis indi-cates the existence of publication bias.CONCLUSION：More high quality prospective randomized,controlled,multi-center studies are needed to confirm the efficacy of Xileisan in the treatment of ulcerative colitis.