索他洛尔治疗房性心律失常57例

Treatment of patients with atrial arrhythmia using sotalol

目的 探讨索他洛尔治疗房性心律失常的临床疗效。方法 对 5 7例服用索他洛尔和 48例服用心律平的房性心律失常病人进行药物疗效及副作用发生率比较 ,并观察服用索他洛尔前后病人的心率、QTc、左室舒张末期内径 (LVD ED)及心脏射血分数 (EF)变化。结果 索他洛尔和心律平治疗房性心律失常的有效率分别为 6 8.4%和 6 6 .0 % ,副作用发生率分别为 16 .0 %和 14 .5 %。索他洛尔组用药后心率和QTc有明显降低和延长 ,LVDED和EF无明显变化。结论 索他洛尔是一种治疗房性心律失常有效且安全的药物。

Objective To investigate the clinical effect of sotalol in treating atrial arrhythmia.Methed The effect and side effect were observed through compairson of oral sotalol and propafenone in patients with atrial arrhythmia. The heart rate,QTc,left ventricle diastole end diameter(LVDED) and ejection fraction(EF)were examined in patients before and after taking sotalol.Result The effect rate of sotalol and propafenone were 68.4% and 66.0% respectively.The side effect incidence were 16.0% and 14.5% respectively.In patients who took sotalol,the heart and QTc rate remarkably reduced and prolonged.but LVDED and EF hadn't changed obviously.Conclusion Sotalol is an effective and safe medicine in treating atrial arrhythmia.