丝素蛋白材料在组织工程中的新进展

A new development of silk fibroin scaffolds in tissue engineering

背景:丝素蛋白支架已被建议运用在组织工程骨和软骨重建、肌腱重建、血管重建,神经重建以及膀胱重建等各方面。目的:总结丝素蛋白作为支架在生物材料和组织工程领域的应用与发展。方法:由第一作者应用计算机检索PubMed数据库及中国期刊数据库2000年1月至2011年11月有关丝素蛋白支架制备工艺,丝素蛋白支架修饰方法及丝素蛋白在组织工程中的应用等方面的文献。结果与结论:丝素蛋白具有机械强度高、生物降解性慢、生物相容性良好、制备工艺多样等特点,支持多种细胞黏附、分化和生长,可应用于人工韧带、血管、骨、神经组织等方面。近期以丝素蛋白支架作为载体,通过多种方式添加各种生物制剂,比如各种生长因子和细胞因子,进一步扩大丝素蛋白在组织工程中的应用范围。

BACKGROUND： Silk fibroin scaffolds have been recommended to use in tissue-engineered bone and cartilage, tendon vessel, nerve, and bladder. OBJECTIVE： To summarize the application and current development of silk fibroin scaffolds in the fields of biomaterials and tissue engineering. METHODS： An online search was conducted by the first author in PubMed database and CNKI database to identify the articles related to silk fibroin scaffold preparation technique, modification of silk fibroin and silk fibroin tissue engineering published from January 2000 to November 2011. RESULTS AND CONCLUSION： Silk fibroin scaffolds has excellent mechanical strength, slow biodegradability, superior biocompatibility and processability. And they can support various cells to attach, differentiate and grow. The scaffolds have been applied in tissue engineering studies, such as artificial ligament, blood vessels, bone, nerve tissue and so on. To date, diverse biologicals, such as growth factors or cytokines, were incorporated therein silk fibroin scaffolds, to further expand the application range in tissue engineering.