原发性肝癌切除术后肝外转移灶的观察

The observation of distant metastasis of primary liver cancer after hepatectomy

目的：探讨原发性肝癌肝外转移的某些特性。方法：收集11年内在我院施行了根治性肝切除术，术后出现肝外转移而肝内无复发的35例肝癌患者的临床资料，进行分析。结果：35例肝癌根治性切除术后，分别于术后1个月到8年出现临床可以查知的转移灶而无肝内复发，其中8例（22．9％）患者于术后3～8年才发现肝外转移灶。结论：肝癌远处小转移灶可以在术后一段时间内持续处于肿瘤休眠状态（最长达7年多），是远期复发的一个重要原因。治疗术后可能存在的小转移灶，对预防术后复发和转移具有重要的意义。

Objective: To investigate some properties of metastasis of primary liver cancer(PLC). Methods: We collected 35 cases of PLC who received radical PLC resection in recent 11 years in our hospital. Distant metastases had been found after operation, but no evidence of intrahepatic recurrence. Result: Distant metastases of these cases were not found in 22. 9% (8/35) patients until three years after operation. Conclusions: Metastases of PLC can persist for up to 7 years in a state of 'tumor dormancy'. It is an important reason for long term recurrence. Therapeutic programs for patients who may exist metastases after operation, would have important significance.