大肠癌p21蛋白和nm23蛋白的表达及其对预后的影响

Expression of p21 protein and nm23 protein in colorectal cancer and their prognostic values

目的：探讨p21蛋白及nm23蛋白的表达与大肠癌临床生物学行为的关系及其临床实用价值。方法：采用免疫组织化学方法（LSAB）分别对206例大肠癌标本进行p21蛋白和nm23蛋白表达的检测、分析。结果：大肠癌p21蛋白的表达与nm23蛋白的表达无明显相关性（r＝-0．1536）。p21蛋白及nm23蛋白的表达与病人年龄、性别、肿瘤部位、大体类型、组织类型、Dukes’分期等无关（P＞0．05）；与病人预后明显相关（P＜0．01），即p21表达越高病人预后越差，而nm23蛋白的表达越高则病人预后越好。结论：大肠癌p21蛋白的异常表达与nm23蛋白的表达紊乱无明显相关性，p21蛋白和nm23蛋白表达的检测有助于大肠癌的临床诊断及预后的评估。

Objective: To explore the relationship between clinicobiological acting and expression of p21 protein and nm23 protein in colorectal cancer. Methods: The intensity of expression of p2l protein and nm23 protein for 206 cases of colorectal cancers were detected by immunohistochemistry assay (LSAB ) respectively. Results: The expression of p21 protien was not correlated with that of nm23 protein for colorectal cancer(r = -0. 1536). The intensity of expression of p21 protein and nm23 protein in colorectal cancers were not related with patient's age, sex, tumor location, pathological type, histological type, Dukes' stage and so on(P > 0. 05 ). Both the expressions were significantly correlated with the prognosis of colorectal cancer (P < 0. 01 ). The higher the intensity of expression of p2l protein the worse the patient's prognosis,and the higher the intensity of expression of nm23 protein the better the patient's prognosis. Conclusions: The abnormal expression of p21 protein is not correlated with the erroneous expression of nm23 protein in colorectal cancer. The detection of p21 protein and nm23 protein are helpful for diagnosis and prognostic evaluation for colorectal cancer.