中国人群孕前队列研究先兆子痫:原理、研究方法和基线结果(英文)

A pre-conception cohort to study preeclampsia in China:Rationale,study design,and preliminary results

目的:目前尚不清楚先兆子痫是由孕前因素还是妊娠因素所引起。本研究通过在中国湖南地区建立孕前队列以阐明先兆子痫的病因。方法:本研究拟在湖南浏阳地区招募5000对半年内有怀孕打算的未孕夫妇,并追踪研究对象的怀孕、分娩及产后情况。结果:目前本孕前队列共招募了1915对未孕夫妇。与孕前相比较,产妇的收缩压和舒张压在孕中早期有所下降,然而在孕后期有所上升。结论:孕前队列的建立将对孕期先兆子痫及产后心血管疾病的预防发挥重要的理论和实际意义。

Objective： It is uncertain whether preedampsia （PE） is caused by pre-existing factors or by pregnancy itself. We want to answer this important question in public health by conducting a large pre-conception cohort in China. Methods： A prospective and pre-conception cohort study with a target recruitment of $000 couples who plan to have a baby within 6 months was performed and their conception, delivery, and postpartum were followed up in Liuyang county, Hunan Province ofP. R. China. Results： A total of 1915 young couples have been recruited into this unique pre-conception cohort till now. In general, both systolic blood pressure and diastolic blood pressure decreased in early second trimester from pre-conception level but increased in third trimester and at delivery. Conclusion： The proposed pre-conception cohort study will have important theoretical and practical implications on the prevention of PE and its associated cardiovascular disease risks.