637例甲真菌病临床类型及致病真菌分析

Clinical investigation and pathogenic fungus analysis of 637 onychomycosis cases

目的了解637例甲真菌病患者的临床分类、致病真菌菌种构成及其分布。方法按甲真菌病诊断标准收集近3a来637例真菌培养阳性甲真菌病患者并临床分类,按真菌学分类标准诊断致病菌种类,分析各菌种在临床病种、年龄段、性别等的分布。结果临床分型以远端侧位甲下型为主(72.06%)。菌种构成为皮肤癣菌占69.39%、酵母菌占18.68%、非皮肤癣菌霉菌占11.93%。皮肤癣菌中红色毛癣菌353株(79.86%),酵母菌中白念珠菌67株(56.30%),非皮肤癣菌中以青霉和曲霉为主。致病菌种的分布在不同年龄段及性别间存在差异,但均以皮肤癣菌为主。结论甲真菌病的临床类型以远端侧位甲下型为主,红色毛癣菌为优势致病菌。

Objective To analyze the clinical features, pathogenic fungus distribution and correlation between fungus and clinical patterns of onychomycosis vdth positive fungal culture in 637 cases. Methods Fuaga｜ culture and clinical analysis were performed on 637 cases of onychomycosis with positive result by fungal cultivation. Results DLSO were the most frequently clinical patterns. Of all the 637 cases of onychomycosis with positive fungal culture. The rates of dermatophytes, yeasts and non-dermatophytic moulds were 69.39%, 18.68% and 11.93% respectively. There are differences between patients with different sex and age. Dermatophytes were the dominate strains. Conclusion In Northwest Beijing region, the dominant clinical type of onychomyeosis with positive fungal culture is DLSO. The most frequent pathogenic fungus of onychomycosis is Trichophyton spp.