生殖器念珠菌病家庭内感染的临床研究

Investigation on genital candidias within couples

目的了解引起夫妻双方生殖器念珠菌病的病原菌是否为同一种致病菌,并行药物敏感性检测,以指导临床治疗。方法采用常规念珠菌培养方法培养,API 20C AUX进行鉴定,微量稀释法行药敏检测。结果 88例患者(44对夫妻)中,检出白念珠菌73例。夫妻双方共同由同一菌种致病例数为41对,白念珠菌引起者为36对,光滑念珠菌引起者为2对,近平滑2对,克柔念珠菌1对。与对照组相比,差异有统计学意义。体外药敏显示88株念珠菌对制霉菌素全部敏感,对克霉唑也高度敏感,对伊曲康唑、氟康唑有不同程度的耐药。结论夫妻一方患有生殖器念珠菌病时,另一方应做好性伴通知工作,行相应检查,必要时行药敏实验,以降低念珠菌病的复发率。

Objective To investigate wether the genital eandidiasis is resulted from the same pathogenic fungus between the cou- ple and to guide the clinic treatment by drug sensitivity test. Methods Use common ways to cultivate candida. API 20C AUX and the microdilution method were used to do identification and drug sensitivity test of candida. Results Eighty-eight genital candida strains were isolated. Fouty-one couples surffered from the same candida, which was significant diffrence compared with the control （ P 〈 0.05 ） Eighty-eight genital eandida strains were senstive to nystatin and elotrimazole, but showed different drug resistenee with itraconazole and flueonazole. Conclusion When one of the couple suffer from genital candidias, the other should have detail examination and individual therapy in order to reduce the rate of recurrence.