半乳糖凝集素1的免疫功能

The Immune Functions of Galectin-1

半乳糖凝集素为S型凝集素,因其可特异性识别β-半乳糖苷键而得名。半乳糖凝集素1是最早发现的半乳糖凝集素家族成员,它在固有免疫与适应性免疫中均发挥着重要的作用。在固有免疫中,半乳糖凝集素1调节中性粒细胞、肥大细胞、巨噬细胞的功能,进而调节免疫反应;在适应性免疫中,半乳糖凝集素1对T细胞有重要的免疫调节功能,在T细胞存活、T细胞免疫调节、T细胞免疫疾病、炎症、肿瘤发生发展及免疫逃逸中都扮演着重要的角色。

Galectins are S-type lsectins with an affinity for 13-galactosides. Galectin-1 is the first described mem- ber of galectin family which plays an important role in both innate and adaptive immunity. In innate immunity, ga- lectin-1 can regulate the function of neutrophils, mastocytes and macrophages then to regulate immune responses. In adaptive immunity, galectin-1 can regulate the immune function of T cells. It contributes greatly to T-cell sur- vival, T-cell immune regulation, T-cell immune disorder, inflammation, tumor progression and tumor immune-es- cape.