摘要
背景:白细胞介素1是强直性脊柱炎易感基因之一,其多态性与疾病易感性相关,不同人群的研究结果不尽相同。目的:分析中国湖北汉族人群中白细胞介素1受体拮抗剂基因多态性与强直性脊柱炎的相关性。方法:自140名强直性脊柱炎患者及130名健康对照者外周血中提取DNA,采用PCR方法检测白细胞介素1受体拮抗剂基因第二内含子VNTR复等位基因多态性。所有受试者均为3代或3代以上居住于湖北的汉族人。结果与结论:强直性脊柱炎患者中白细胞介素1受体拮抗剂基因*2等位基因频率显著高于健康对照者(P<0.05)。提示强直性脊柱炎与白细胞介素1受体拮抗剂基因*2等位基因相关联。
BACKGROUND:Interleukin 1(IL-1) gene cluster contains a major susceptibility locus for ankylosing spondylitis.Its polymorphisms are correlated with the susceptibility of ankylosing spondylitis.The study results are often different in different population.OBJECTIVE:To analyze the correlation between polymorphism of IL-1 receptor antagonist(IL-1RN) gene and patients with ankylosing spondylitis.The patients are the population of Han nationality of Hubei Province in China.METHODS:DNA samples were collected from 140 patients with ankylosing spondylitis and 130 healthy as controls.The IL-1RN VNTR polymorphisms were determined by PCR method.All patients are of Han nationality and lived in Hubei Province for three generations at least.RESULTS AND CONCLUSION:Compared with the healthy controls,IL-1RN VNTR*2 allelic frequency in patients with ankylosing spondylitis was significant higher(P0.05).
出处
《中国组织工程研究》
CSCD
2012年第42期7977-7980,共4页
Chinese Journal of Tissue Engineering Research
基金
武汉市卫生局科研基金资助项目(WX11Z06)~~