摘要
目的：探讨低分子肝素钠（法安明）在急性脑梗死（ＡＩＳ）治疗中的有效性和安全性。方法：对入选的９８例ＡＩＳ病人随机对照研究，法安明组５６例，对照组４２例。根据ＣＳＳ对两组ＡＩＳ病人治疗前后的神经功能状况进行分析比较，同时对比观察两组病人出血性合并症及病死率发生情况。结果：法安明组总体疗效优于对照组（ Ｐ＜ ０． ０５）。在椎基底动脉（ ＶＢＡ）系统中法安明组优于对照组，疗效有显著差异（ Ｐ＜ ０． ０２５）。在安全性方面，法安明与出血性合并症及病死率与对照组无显著差异。结论：法安明治疗ＶＢＡ系统ＡＩＳ安全、有效。
Objective: To evaluate the efficacy and safety of Fragmin in the treatment of acute ischemic stroke (AIS). Methods: 98 cases of AIS patients were studied by comparison randomly. There were 56 cases in Fragmin group, 42 cases in control group. The neurologic outcome of all these patients pre - and post - treatment was observed with CSS, and the occurrence of bleeding events and mortality. Results: The therapeutic effect of Fragmin group was superior to that of control group in all cases (P<0. 05). The data showed that the therapeutic effect in VBA system Fragmin group was better than in control group (P < 0. 025 ). Fragmin's use was not associated with the clinically relevant bleeding risks and mortality. Conclusions: Fragmin is effective and safe in the treatment of AIS of VBA system.
