生长抑素与生长激素促进肠外瘘自愈的机理与临床研究

Somatostatin and growth hormone promote spontaneous closure of enterocutaneous fistula

目的 探索促进肠外瘘自愈的方法。 方法 用 90只雄性SD大鼠进行动物实验 ,研究生长激素对肉芽组织及肠粘膜上皮细胞的作用 ;观察 2 9例肠外瘘患者临床联合应用生长抑素、生长激素与营养支持治疗的效果 ,并与 5 8例用生长抑素加营养支持组对比。 结果 生长激素可促使肉芽组织的羟脯氨酸和纤维母细胞含量增加 ,促进肠粘膜上皮细胞增长。临床联合用药组的自愈率为 96 5 % (2 8/ 2 9) ,明显高于生长抑素组的 6 8 4% (39/ 5 8) ,差异有显著性意义 (P <0 0 1)。 结论 生长抑素加生长激素可促进肠外瘘的自愈 ,是一新的治疗方法。

Objective[WT5”BZ] To find out the method for promoting spontaneous heal of enterocutaneous fistula. [WT5”HZ]Methods[WT5”BZ] Experimentally, we investigated the effect of rhGH on wound granulation and intestinal mucosa. Clinically, combined somatostatin and rhGH was compared with somatostatin in the treatment of enteric fistula. [WT5”HZ]Results[WT5”BZ] Animal studies demonstrated that rhGH was effective to increase the content of hydroxyproline and amount of fibroblast cell in wound granulation. In clinical trial, the spontaneous cure rate was significantly higher in patients treated with combined rhGH and somatostatin than in those treated with somatostatin alone ( 96 5% vs 68 4%, P <0 01). [WT5”HZ]Conclusion[WT5”BZ] Combined rhGH and somatostatin is a new therapeutic method for the treatment of enteric fistula. It may promote the spontaneous cure of enteric fistula. [WT5”HZ]