威海市1636例乳腺癌患者不同治疗策略与预后的相关性分析

Analysis on the relationship of different treatment strategies and prognosis of 1636 patients with breast cancer in Weihan City

目的通过对大样本乳腺癌治疗相关策略与预后关系分析,建立具有临床实用价值的预后模型,为乳腺癌防治提供科学依据。方法对解放军第404医院、威海市立医院(包括总院及南院区)、威海市妇女儿童医院2005-01～2009-12收治的具有明确组织类型和TNM分期的1636例乳腺癌患者,经查阅病历并随访,回顾性分析、比较治疗策略对乳腺癌患者生存预后的影响。结果共随访1636例乳腺癌患者,失访154例,随访率90.6%,有效病例1482例。治疗相关因素包括手术、化疗方案的选择、放疗在内的3个变量,均与远期生存相关(P<0.05)。结论在乳腺癌治疗策略中,手术、化疗方案的选择及放疗是威海市乳腺癌患者预后的独立影响因素。

Objective Through analysis of relationship of a large sample of breast cancer tumors and prognosis factors to establish a clinical practical prognostic model, so as to provide the scientific basis for preventing ＆ treating breast cancer. Methods In the PLA No. 404 hospital, Weihai municipal hospital （including institute and south ward area）, Weihai municipal hospital for women and children from January 2009 to December 1636 cases of patients with breast cancer were involved this study, Through reading medical records and follow- up, retrospective analysis and comparison on related influence of treatment strategies on survival prognosis were taken. Results In follow-up of 1636 breast cancer patients, 154 cases lost, follow-up rate was 90.6%, i.e 1482 cases were effective. Treatment related factors including surgery, chemotherapy, radiation therapy, the choice of the three variables were related to breast cancer patients long-term survival （P〈0.05）. Conclusion Treatment related strategies including surgery, chemotherapy, radiation therapy, the choice of the three variables are independent prognostic factors influencing long-term survival of breast cancer patients.