脑白质疏松危险因素的回归分析

Risk Factors for Leukoaraiosis: A Logistic Regression Analysis

目的探讨脑白质病变的危险因素。方法以脑血管病入院的患者204例,以白质病变等级为因变量,可能的影响因素为自变量,采用SAS 9.2软件进行非条件Logistic回归分析。显著性水平α=0.10。结果共有5个因素纳入回归方程:有无狭窄、年龄、低密度脂蛋白、载脂蛋白B和载脂蛋白A,前4项为危险因素(OR>1,P<0.05),载脂蛋白A为保护因素(OR=0.715,P=0.0993)。结论动脉粥样硬化的危险因素同样为脑白质病变的危险因素;脑白质病变与颈部大血管狭窄密切相关。

Objective To investigate the risk factors for leukoaraiosis. Methods 204 cases of inpatients were registered. The severity of leukoaraiosis was as the dependent variable, the possible risk factors were as independent variables, unconditional logistic regression was analyzed with SAS 9.2 software, significant level a=0.10. Results 5 factors, that were carotid stenosis, age, low density lipoprotein cholesterol, apolipoprotein B and apolipoprotein A, were included, in which the former 4 were risk factors （OR〉1, P〈0.05）, the latter was protection factor （OR=0.715, P=0.0993）. Conclusion The vascular risk factors contribute to formation of leukoaraiosis, and carotid stenosis relate to leukoaraiosis.