摘要
新的和 16 已知的混合物被孤立从受苦 sibirica。他们的结构主要根据 NMR 和 MS 被分配分光镜的数据。在为对四个人的肿瘤房间的 anti-proliferative 活动的生物鉴定，与 0.9 g/mL 的 IC50 价值对 COLO-205 肿瘤房间加重 7 展出选择 anti-proliferative 活动。
One new and 16 known compounds were isolated from Abies sibirica. Their structures were assigned mainly on the basis of NMR and MS spectroscopic data. In bioassay for anti-proliferative activity against four human tumor cells, compound 7 exhibited selective anti-proliferative activity against COLO-205 tumor cell with an IC50 value of 0.9 μg/mL.
基金
supported by program NCET Foundation
NSFC(No.30725045)
partially supported by Global Research Network for Medicinal Plants(GRNMP)
King Saud University,Shanghai Leading Academic Discipline Project(No.B906),FP7- PEOPLE-IRSES-2008(TCMCANCER Project 230232)
Key Laboratory of Drug Research for Special Environments,PLA,Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(No.10DZ2251300)
the Scientific Foundation of Shanghai China(No.09DZ1975700,09DZ1971500, 10DZ1971700)
the Twelfth Five-Year National Science & Technology Support Program(No.2012BAI29B06)
