伴与不伴自杀行为的抑郁症患者临床症状及血清脑源性神经营养因子水平比较

Clinical symptoms and serum brain.derived neurotrophic factor lever between depressive patients with and without attempted suicide behavior

目的比较伴与不伴自杀行为的抑郁症患者临床症状及血清脑源性神经营养因子（BDNF）水平差异。方法采用酶联免疫双抗体夹心法测定抑郁症自杀未遂患者（n=36）和无自杀行为抑郁症患者（n=55）血清BDNF水平，并以汉密顿抑郁量表（HAMD）评定抑郁严重程度。结果自杀未遂组HAMD总分高于无自杀行为组（t=3．632,，P=0．000），自杀未遂组HAMD因子认识障碍（t=-2．339，P=0．019）和绝望感（t=-2．812，P=0．005）高于无自杀行为组，两组因子焦虑／躯体化、体质量、日夜变化、阻滞和睡眠障碍等评分差异均无统计学意义（均P〉0．05）。自杀未遂组血清BDNF水平低于无自杀行为组（t=-2．122，P=0．037）；不同性别间血清BDNF水平差异无统计学意义（P〉0．05）。结论伴自杀行为的抑郁症患者临床症状有一定特征性，血清BDNF水平低对评估抑郁症自杀风险有重要意义。

Objective To explore the characteristics of clinical symptoms and serum brain-derived neurotro- phic factor （BDNF） level between depressive patients with and without attempted suicide behavior. Methods Serum BDNF level in depressive patients with （ n = 36 ） and without （ n = 55 ） attempted suicide behavior were assayed by ELISA,the severity of depression was measured by Hamilton rating scale for depression （HAMD）. Results HAMD- 24 total scores （ t = 3. 632, P = 0. 000）, cognitive disturbance （ t = - 2. 339, P = 0. 019 ） and hopelessness factor scores （t = -2. 812, P = 0. 005 ） in depressive patients with attempted suicide behavior were significantly higher than those in depressive patients without attempted suicide behavior. There were no siguificant differences of anxiety/soma- tization,body weight, diurnal variation, psychomotric inhibition and sleeping disturbance fator scores between two groups （P 〉0.05 ）. The serum BDNF level in depressive patients with attempted suicide behavior was significantly lower than that in depressive patients without attempted suicide behavior （ t = - 2. 122 ,P = 0. 037 ）. There was no sig- nificant difference of serum BDNF level between male and female patients （ P 〉 0.05 ）. Conclusion There were cer- tain characteristics on clinical symptoms of depressive patients with attempted suicide behavior. The low sernm BDNF level might play an important role in the risk of suicide in depressive patients.