经皮冠状动脉介入术对急性心肌梗死患者血浆脑利钠肽水平的影响

Effect of percutaneous coronary intervention on level of brain natriuretic peptide of acute myocardial infarc- tion patients

目的探讨经皮冠状动脉介入术（PCI）对急性心肌梗死（AMI）患者血浆脑利钠肽水平的影响。方法200例AMI患者按治疗方法不同分为给予PCI治疗的观察组和溶栓治疗的对照组，检测治疗后6h、12h、24h和48h时外周血脑利钠肽水平以及心脏功能相关指标。结果观察组治疗后6h开始BNP水平明显低于治疗前（t=5．382、9．493、12．482，均P〈0．05）；对照组治疗后12h开始BNP水平明显低于治疗前（t=7．831、12．184，均P〈0．05）；治疗前和治疗后48h时，两组BNP水平差异均无统计学意义（均P〉0．05）。观察组中BNP〈100ng／L组sT段抬高程度明显低于≥100ng／L组（t=9．472，P〈0．05）、左心室舒张末期直径、左室射血分数明显高于≥100ng/L组（t=6．932、5．532，均P〈0．05）。结论采用PCI治疗AMI患者，能够在较短时间内降低BNP水平、改善心脏功能，具有积极的治疗意义。

Objective To study the level of brain natriuretic peptide of acute myocardial infarction （AMI） patients given percutaneous coronary intervention （PCI）. Methods 200 patients with AMI were collected and randomly divided into observation group given PCI and control group given thrombolytic therapy. Then level of BNP 6h, 12h,24h and 48h after treatment was detected and cardiac function indexes were observed. Results BNP level of observation group began to reduce from 6h （ t = 5. 382,9. 493,12. 482, all P 〈 0.05 ）, control group began to reduce from 12h （t = 7. 831,12. 184, all P 〈0. 05 ） ; ST segment elevation of BNP 〈 100ng/L group was significantly lower than that of ≥100ng/L group （ t = 9.472,P 〈 0.05 ） ; LVEDD, LVEF were significantly higher than those of ≥ 100ng/L group （ t = 6. 932,5. 532, all P 〈 O. 05 ）. Conclusion PCI can decrease level of BNP and improve heart function in a relatively short time and has positive therapeutic significance.