COX-2在甲状腺相关眼病眼眶脂肪增生中的作用

Research progression on cyclooxygen-2 in adipogenesis of thyroid associated ophthalmopathy

甲状腺相关眼病（thyroid-associatedophthalmopathy，TAO）是一种自身免疫性疾病，发病机制与成纤维细胞和T细胞的相互作用所致炎症反应有关，脂肪增生是其重要的病理过程。环氧化酶-2（cyclooxygenase-2，COX-2）是一种重要的致炎因子，与多种自身免疫疾病的炎症过程相关。TAO患者眼眶中活化的T淋巴细胞过量表达COX-2，并通过与眼眶CD90-成纤维细胞表达的过氧化物酶体增生物激活受体1（peroxisomeproliferatoractivatedreceptor1，PPARγ）结合，诱导CD90-眼眶成纤维细胞分化为成熟脂肪细胞，从而促进眼眶脂肪增生的发生，因此COX-2在TAO眼眶脂肪增生中起重要作用。（国际眼科纵览，2012，36：336-340）

Thyroid associated ophthalmopathy （TAO） is an autoimmune disease, it＇ s pathogenesis related to the inflammation caused by reaction between T cell and orbital fibroblasts, and adipogenesis is an important pathological procedure. Cyclooxygenase-2 （ COX -2） is an important proinflammatory factor associ- ated with inflammatory process of various autoimmune diseases. Recent studies have shown that COX-2 plays an important role in TAO orbital fat proliferation. Activated T lymphocytes in the orbit of TAO patients over- express COX-2, which could induct the differentiation of CD90 - orbital fibroblasts into mature adipocytes through combination with peroxisome proliferator activated receptor γ （PPARγ） expressed on the surface of CD90- orbital fibroblasts, thereby promoting the occurrence of orbital fat proliferation. （Int Rev Ophthal- mol, 2012, 36： 336-340）