摘要
An efficient method for the synthesis of N-Cbz-β-aminoalkanesulfonamides was described.N-Cbz-β-aminoalkanesulfonamides were readily prepared in good yields from a variety of amino alcohols,including optically active ones,via N-Cbz protection with benzyl chloroformate,Mitsunobu esterification reaction with thiolacetic acid,N-chlorosuccinimide oxidation,and ammonolysis process.
An efficient method for the synthesis of N-Cbz-β-aminoalkanesulfonamides was described. N-Cbz-β-aminoalkanesulfonamides were readily prepared in good yields from a variety of amino alcohols, including optically active ones, via N-Cbz protection with benzyl chloroformate, Mitsunobu esterification reaction with thiolacetic acid, N-chlorosuccinimide oxidation, and ammonolysis process.
基金
the support from the National Natural Science Foundation of China(20973013)
Beijing Natural Science Foundation(2092022)
