中药止痛作用与中医证型相关性的实验研究

Experimental research on the relationship between analgesic effect of Chinese medicine and syndromes types of TCM

目的:研究中药止痛作用与中医证型的相关性。方法:将大鼠随机分成风湿痹痛证实验组与瘀血痛证实验组,再分别将2个实验组随机分为正常对照组、模型组、桂枝组、三七组、威灵仙组、甘草组和冰片组,采用酶联免疫(ELISA)法检测各组大鼠血清白细胞介素-2(IL-2)、白细胞介素-8(IL-8)、前列腺素E2(PGE2)的水平。结果:在风湿痹痛证实验中,与模型组比较,威灵仙组大鼠IL-2、PGE2水平明显降低(P<0.01);在瘀血痛证实验中,与模型组比较,三七组大鼠IL-2、IL-8、PGE2水平明显降低(P<0.01)。结论:中药的止痛作用与中医证型具有一定相关性。

Objective： To study the relationship between analgesic effect of Chinese Medicine and syndromes types of TCM.Methods： Rats were randomly divided into wind dampness stasis syndrome test group and blood stasis syndrome test group.The two group were respectively divided into 7 groups： control group,model group,cinnamomi group,notoginseng group,radix clematidis group,glycyrrhizae group and borneol group.IL-2,IL-8 and PGE2 level of each rat in serum were determined by ELISA method.Results： In wind dampness stasis syndrome test,compared with model group,IL-2 and PGE2 level of radix clematidis group were remarkable lower（P0.01）;in blood stasis syndrome test,compared with model group,IL-2,IL-8 and PGE2 level of notoginseng group were remarkable lower（P0.01）.Conclusion： The analgesic effect of Chinese Medicine maybe related with the syndromes types of TCM.